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Purpose One of the most important issues to address when developing an optimal screening system for prostate cancer is investigating appropriate biopsy indications following serum prostate-specific antigen (PSA) measurements in order to maintain high sensitivity and avoid unnecessary biopsy. Methods Between April 2004 and December 2007, 239 consecutive men with total PSA levels of 2.0–10.0 ng/mL...
Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b
OBJECTIVE• To assess variation of total prostate‐specific antigen (tPSA), free PSA (fPSA), percent fPSA, human glandular kallikrein 2 (hK2) and intact PSA measured three times within 2 weeks. Knowledge of the variation in an individual’s PSA level is important for clinical decision‐making.
PATIENTS AND METHODS• Study participants...
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