The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The ordered electrical stimulation of the ventricles is achieved by a specialized network of fibres known as the Purkinje system. The gross anatomy and basic functional role of the Purkinje system is well understood. However, very little is known about the detailed anatomy of the Purkinje system, its inter-individual variability and the implications of the variability in ventricular function, in part...
We present a method to automatically deploy the peripheral section of the cardiac conduction system in ventricles. The method encodes anatomical information thorough rules that ensure that Purkinje network structures generated are realistic and comparable to those observed in ex-vivo studies. The core methodology is based in non-deterministic production rules that are parameterized by means of statistical...
Introduction: Conducted electrical weapons (CEW) have generated controversy in recent years regarding their effect on heart rhythm and on their suspected interaction with implanted devices such as the pacemakers and ICDs (implantable cardioverter defibrillators). We review the current evidence available on device interactions and pre-sent a new case series of 6 patients. Literature: We used the available...
High performance computing is required to make feasible simulations of whole organ models of the heart with biophysically detailed cellular models in a clinical setting. Increasing model detail by simulating electrophysiology and mechanical models increases computation demands. We present scaling results of an electro-mechanical cardiac model of two ventricles and compare them to our previously published...
In order to translate the important modelling work into clinical tools, the selection of the best model for a given application is crucial. In this paper, we quantitatively compare personalization of two different cardiac electrophysiology models on the same dataset, in order to help such a selection. One is a phenomenological model, the Aliev-Panfilov model (1996), and the other one is a simplified...
In this study, a computational framework combining state-of-the-art cardiac simulation software and Grid computing is used to investigate the impact of the block of the HERG current on the ECG waveform using state-of-the-art 3D ventricular models of electrophysiology. The technology developed enables (i) automated parameter sweeping using multiscale models (from ion channel to ECG) and (ii) reduced...
Electrophysiological cardiac data mapping is an essential tool for the study of cardiac rhythm disorders, such as atrial fibrillation. Over the past decade, various advanced cardiac mapping systems have been developed to create detailed cardiac maps and assist physicians in diagnosis and therapy guidance. While these systems have increased the ability to study and treat cardiac arrhythmias, inherent...
Experimental studies show an increased vulnerability to atrial fibrillation (AF) in acutely dilated atria. By application of a stretch-activated channel (SAC) blocker, vulnerability to AF decreases significantly, indicating a role for SACs in the initiation of AF. Using a computer model of cardiac electromechanics, we investigate the hypothesis that increased vulnerability to AF may be attributed...
We develop a mechanical model for catheters and other interventional devices which are steered by externally applied magnetic fields. Each device contains a permanent magnet near its distal tip. The external magnetostatic field, whose direction and magnitude can be selectively varied, is applied to the vicinity of the tissue where the medical procedure is being performed, in order to orient the catheter...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.