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Glucocorticoids (GCs) are essential for normal brain development; however, there is consistent evidence that prenatal exposure of the fetal brain to excess GCs permanently modifies the phenotype of neuronal cells. In this paper, the murine-derived multipotent stem cell line C17.2 was used, as an in vitro model, to investigate the impact of GCs on neural stem cell survival. Our results indicate that...
-Hippocampal neurons are among the first neuronal cells to degenerate in the brain of patients affected by Alzheimer's disease (AD). These neurons have endogenous glucocorticoid receptors (GRs) and are vulnerable to oxidative stress that has been implicated in the pathogenesis of AD. The activities of various steroids can have an impact on neuronal function and the sensitivity of neurons to different...
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