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Background HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patient treatment is the emergence of multidrug resistant PRs (mdrPRs). This study aimed to develop a fission yeast cell-based system for rapid testing of new PIs that combat mdrPRs. ...
This chapter briefly summarizes what we currently know about some of the biological changes that accompany aging, and then tries to predict which of these may be the most relevant to the onset of age-related cardiac pathology, and the ultimate need for cardiothoracic surgery in older persons. Although cardiovascular diseases are now the major cause of mortality in developed countries, and age is a...
Wallerian degeneration in the dorsal columns (DC) after spinal cord injury (SCI) is associated with microglial activation and prolonged oligodendrocyte (OL) apoptosis that may contribute to demyelination and dysfunction after SCI. But, there is an increase in OL lineage cells after SCI that may represent a reparative response, and there is evidence for remyelination after SCI. To assess the role of...
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