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To investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.The study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8Gy×1) or multiple-fraction (3Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue...
Recent randomised studies have reported that single fraction radiotherapy is as effective as multifraction radiotherapy in relieving pain caused by bone metastasis. However, there are concerns about the higher re-treatment rates and the efficacy of preventing future complications, such as pathological fracture and spinal cord compression, by single fraction radiotherapy. A systematic review of randomised...
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