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Panoramic images providing a larger local overview of the internal urinary bladder wall can be used for documentation and surgery planning, as well as assist the re-identification of multi-focal tumors during a cystoscopy. In contrast to white light illumination, the photodynamic diagnosis (PDD) leads to an enhanced tissue contrast, resulting in a reddish fluorescence of malignant tissue excited by...
Endoscopic treatment of bladder cancer is more and more often based on photodynamic diagnostics (PDD), a specialized endoscopic technique where a narrow-band bluish illumination causes tumors to fluoresce reddish. Contrast between tumors and healthy bladder tissue is thus noticeably increased compared to white light endoscopy. A downside of PDD is the low illumination power, which requires that the...
Fluorescence endoscopy is an emerging technique for the detection of bladder cancer. A marker substance is brought into the patient's bladder which accumulates at cancer tissue. If a suitable narrow band light source is used for illumination, a red fluorescence of the marker substance is observable. Because of the low fluorescence photon count and because of the narrow band light source, only a small...
Two systems were used for imaging. The first was a combined optical coherence tomography(OCT)/laser induced fluorescence(LIF) instrument, with a 1310 center wavelength OCT source and a 633 nm He:Ne laser for excitation of the Cy5.5 dye. The OCT and LIF channels were combined into a 2 mm diameter endoscope.
Bladder tumors are difficult to recognize during an endoscopy of the bladder (cystoscopy) using a conventional white light source. Therefore, a technique called photo dynamic diagnosis (PDD) or fluorescence endoscopy is used to enhance both sensitivity and specificity of tumor detection. As preparation for a PDD cystoscopy, a marker substance is brought into the patient's bladder which leads to a...
The article consists of a Powerpoint presentation on optical technologies for early GI cancer detection. The areas discussed include: optical diagnostics; white-light endoscopy; optical coherence tomography; microendoscopy; endocytology; fluorescence endoscopy; Raman spectroscopy; confocal microscopy; diffuse reflectance spectroscopy and elastic scattering spectroscopy etc. etc.
Human tissues show autofluorescence emission spectra when excited by ultraviolet or short-wavelength visible light. The intensity and shape of these spectra depends of the tissues pathologic state. Therefore, its measurement can give information about the degree of malignant transformations that could lead to cancer. This paper describes the design of an integrated CMOS compatible fluorescence measurement...
This paper describes the design, fabrication and characterization of CMOS optical sensors for cancer detection based on autofluorescence emission spectra. These optical sensors were fabricated for being an integrated part of an endoscopic capsule used in diagnosis of gastrointestinal diseases. Cells and tissues show autofluorescence, in a part of the visible spectrum, when excited by ultraviolet or...
Fluorescence endoscopy is a novel imaging technique that offers a non-invasive means to diagnose and stage cancers without the need to conduct biopsies of suspected lesions. Work carried out by our research group showed that fluorescence diagnosis can be further enhanced by incorporating a ratio diagnostic algorithm in the system. Currently images captured using these imaging techniques have to be...
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