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Optical imaging is unequivocally the most versatile and widely used visualization modality in clinical practice and life sciences research. In recent years, advances in photonic technologies and image formation methods have received particular attention in biological research and the drug discovery process for non-invasively revealing information on the molecular basis of disease and treatment. An...
We present the technology and application regimes of multi-spectral optoacoustic tomography and showcase its high resolution imaging performance in imaging fluorochromes, fluorescent proteins and other chromophoric agents in-vivo.
Photoacoustics (PA) combines the high contrast of optical imaging modalities with the high resolution of clinical ultrasound. Fluorescence mediated tomography (FMT), on the other hand, offers a very high molecular contrast specificity. Therefore, a combination of PA imaging and FMT might be fruitful: e.g. PA imaging could provide valuable a priori information for optical-tomography reconstruction...
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