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The objective of this contribution is to investigate and evaluate the impact of modeling the directional aspects of the electrical conductivity of the heart muscle tissue in computational myocardium defibrillation analyses. The primary purpose of this study is to clarify the potential advantages and associated costs of applying a variety of increasingly detailed conductivity models to represent the...
During a defibrillation shock, epicardial conductors can introduce antistimulatory effects due to lowering of the voltage gradient in myocardial tissue under the conductor and stimulatory effects due to membrane polarization near edges. We hypothesized that increasing the area of conductors increases the defibrillation threshold (DFT), while increasing the amount of stimulatory edge of conductors...
The automatic implantable defibrillator delivers a shock directly to the heart. Optimal strategies for delivering these shocks were determined by studying a three-dimensional computer model of the electric fields produced by internal defibrillation electrodes. A finite-element technique was used to determine energy and current distribution in the heart for electrode configurations typically in use...
An approach called voltage-sensitive-dye recording is introduced for the study of electrical defibrillation of the heart. Voltage-sensitive dyes (VSDs) are molecular probes which transduce cellular potential into an optical signal. Specifically, the optical signals produced by VSDs can be used to follow the time-course of cardiac action potentials. This style of recording is advantageous because the...
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