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Non-linear and anisotropic heart valve leaflet tissue mechanics manifest principally from the stratification, orientation, and inhomogeneity of their collagenous microstructures. Disturbance of the native collagen fiber network has clear consequences for valve and leaflet tissue mechanics and presumably, by virtue of their intimate embedment, on the valvular interstitial cell stress–strain state and...
In our previous work, we proposed a process optimized hollow silicon (Si) microneedle structure on a silicon chip, which had the highest aspect ratio (AR) reported so far. The 150 micrometer (μm) tall optimized microneedle structure with an AR of about 30:1 was fabricated by reactive ion etch or RIE process on a p-type 500 μm thick Si substrate for drug delivery applications. In this paper we have...
Though cartilage tissue is susceptible to damage and difficult to self-repair, cartilage tissue engineering provides an ideal way for the treatment of cartilage defects. Mechanical environments have significant effects on the growth and development of cartilage. The research of mechanical states of repaired articular cartilage by tissue engineering has significantly clinical value. According to the...
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