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The regeneration of the tendon to bone insertion site affects how well the ACL heals. The addition of a calcium phosphate coating to a tendon graft can help to promote osteointegration and healing of the insertion. Patellar tendons were harvested from neonatal bovines and coated in semi-crystalline calcium phosphate. The tendons were subjected to two 5?? concentrated simulated body fluid solutions...
In this study, a calcium phosphate cement was developed, which was injectable and could be molded into any desired shape. The powder component consisted of an equimolar mixture of tetracalcium phosphate and dicalcium phosphate anhydrous. The liquid component consisted of chitosan (3 wt%), citric acid (5 wt%) and glucose (15 wt%) solution. The mechanical properties and biocompatibility of the cement...
Calcium phosphate cement (CPC) sets in situ to form hydroxyapatite and is highly promising for a wide range of clinical applications. However, its low strength limits its use to only non-stress applications, and its lack of macroporosity hinders cell infiltration, bone ingrowth and implant fixation. The aim of this study was to develop strong and macroporous CPC scaffolds by incorporating chitosan...
Comminuted fracture is still a medical problem because of the difficulties for the small bone pieces fixation. Bone adhesive is one of the most potential methods to solve the problem. However, there are a lot of defects in the present medical adhesives. Some adhesives will produce certain poisonous substance in body which would be harmful to people's health. Some have worse adhesive strength and degrade...
Human bone is a hydroxyapatite HAp (HCa5O13P3) and type I collagen based composite. Nowadays, many methods and techniques have been developed and applied to design advanced materials for bone replacement. A strategy for imitating in a tridimensional way the structure, composition and mechanical properties of a bone is mimicking it at nanometric scale. This can be carried out, by incorporating selective...
The purpose of this study was to prepare a 3D nanocomposite bone substitute prepared from gelatin (GEL) and synthesized hydroxyapatite (HAP) in order to mimic natural bone feathers through a novel layer solvent casting combined freeze-drying technique. The adhesion between superimposed layers was ensured by applying a GEL solution. Furthermore, samples were cross-linked with 1% glutaraldehyde (GA)...
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