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A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to have a high complexation affinity with lanthanoid metals. Here we describe the design, synthesis, solid‐state structure, binding constant, and some MRI applications of the Gd‐TEMDO...
Contrast Agents Herein, the efforts in developing a new class of contrast agents based on tetrazoles are described, which replace the carboxylate moiety. A comparable chelating behavior, as tetrazoles are bioisosteres of carboxylic acids, was expected. Furthermore, contrast enhancement in a variety of tissues should be retained. The model example of MRI contrast agents is Dotarem. In the Frontispiece,...
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