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We hypothesize that selected genetic and/or epigenetic changes associated with advanced tumours may help identifying early non-small cell lung cancers (NSCLCs) that recur after resection. Among epigenetic changes, long interspersed nuclear element-1 (LINE-1) hypomethylation is seen early during carcinogenesis and may act in concert with genetic alterations to cancer progression. LINE-1 hypomethylation...
Seules sont abordées les tumeurs de stades I, II et IIIA des cancers bronchiques non à petites cellules accessibles à un traitement local. Cette mise au point tente de répondre à cinq questions posées par les stratégies de combinaison des traitements locaux avec la chimiothérapie. Dans les stades IIIA, si la chimiothérapie augmente la résécabilité des tumeurs, cette efficacité n'induit pas fatalement...
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