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One of the original views about motor convulsions with bilateral synchronous EEG discharges was that ascending projections from deep midline brainstem neurons subserve discharge synchronisation. We examined this in kainic acid- and picrotoxin-induced seizures using the distribution of Fos protein expression in the brainstem as a possible marker of brainstem neuronal activation. Before seizure, Fos...
Induction of Fos in neurons by intraperitoneal injection of 2-buten-4-olide (2-B4O), an endogenous satiety substance, was studied immunohistochemically in the brainstem and spinal cord of the rat. Rats injected intraperitoneally with 2-B4O (100 mg/kg) were allowed to survive for 2 h before perfusion. Fos-like immunoreactivity was observed in neurons of the intermediolateral nucleus, ventral reticular...
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