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Mitochondria are highly dynamic organelles that undergo permanent fusion and fission, a process that is important for mitochondrial function and cellular survival. Emerging evidence suggests that oxidative stress disturbs mitochondrial morphology dynamics, resulting in detrimental mitochondrial fragmentation. In particular, such fatal mitochondrial fission has been detected in neurons exposed to oxidative...
The permeability transition pore (PTP) is a channel of the inner mitochondrial membrane that appears to operate at the crossroads of two distinct physiological pathways, i.e., the Ca 2+ signaling network during the life of the cell, and the effector phase of the apoptotic cascade during Ca 2+ -dependent cell death. Correspondingly, two open conformations of the PTP can also...
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