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Steatosis, i.e., the accumulation of fat in hepatocytes, plays an important role in the progression of non-alcoholic fatty liver disease (NAFLD). It has been shown that STAT3 activation is involved in a decrease of lipid accumulation while C/EBP/ is correlated with an increase of fat content and steatosis. It is known that STAT3 and C/EBP/ are activated by IL-6 and that IL-6 signalling is also affected...
Based on the clinical date of the Peginterferon Alfa-2a plus Lamivudine (combination therapy) for HBeAg-Positive chronic hepatitis B patients, this paper sets up a mathematical model consisting of two differential equation systems that enable us to describe and understand the dynamics of host cells, virus and the immune system. Our model provide a possible interpretation for the effect of combination...
The pathogenesis of chronic hepatitis B is very complex, Systems biology can help us understand it by considering the body, virus and immune system as a whole. Mathematical model including HBV, hepatocytes and the immune system was established in this paper describing the interaction of virus and immune system. The model considered not only the side that hepatitis B virus can evoke the immune system,...
Abnormal functioning of different organs such as pancreas, liver and/or body tissues can result in excessive blood glucose concentration in type II diabetic patients. Although a number of models have been developed for evaluating type I diabetes mellitus, there is limited evaluation for patients with type II. This paper presents the development of a model for type II diabetic patients based on a detailed...
Based on a patient's anti-hepatitis B virus (HBV) infection therapy clinical data of a new type of Chinese herbs (NTCH, consisting of 13 ingredients) plus adefovir dipivoxil, and our previous modified basic virus infection model [1], a new differential equation model with an immune variable is set up, and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well...
In image-guided surgery and image-directed therapy a plan based on pre-procedure imaging is registered to the patient in the operating or treatment room using a 3D spatial localizer. The plan can be used as long as the transformation between plan and patient remains valid. Most systems use a rigid-body transformation restricting guidance to bony structures (e.g. orthopaedic surgery or maxillo-facial...
We have built a collection of flexible, hepatomimetic, in silico components. Some are agent-based. We assemble them into devices that mimic aspects of anatomic structures and the behaviors of hepatic lobules (the primary functional unit of the liver) along with aspects of liver function. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers (IPRLs)...
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