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Gene Selection is very important problem in the classification of serious diseases in clinical information systems. A limitation of these gene selection methods is that they may result in gene sets with some redundancy and yield an unnecessary large number of candidate genes for classification analysis. In the current work, a hybrid approach is presented in order to classify diseases, such as colon...
We investigate the protective effects of VnA against lung injury induced by hepatic ischemia/reperfusion and its possible mechanism in rats. Forty male Wistar rats were randomly divided into control group, hepatic ischemia reperfusion group, low and high dose VnA pretreatment group. Hepatic I/R reduce lung injury characterized by histological changes and lung water content increasing. VnA pretreatment...
In molecular biology, Gene Ontology (GO) has often been used for annotation and as a data mining dimension. A frequently performed step in microarray analytics is the clustering of co-expressed genes by their GO bioprocesses. Biological deductions are then made from the visual representation of the cluster pattern. Thus far, the question of how different representations of GO-annotated clusters affect...
Gene and drug therapy for organ-specific diseases in part depends on the efficient delivery to a particular region of the body. We examined the biodistribution of a viral envelope commonly used as a nanoscale gene delivery vehicle using positron emission tomography (PET) and investigated the magnetic alteration of its biodistribution. Iron oxide nanoparticles and 18F-fluoride were encapsulated by...
IgE plays essential roles in the pathogenesis of many allergic disorders including bronchial asthma, allergic rhinitis, atopic dermatitis, and anaphylaxis. If IgE production can be effectively and safely controlled in patients, such procedures may alleviate allergic symptoms, leading to novel therapeutic and prophylactic interventions of allergic diseases. Interleukin-21 (IL-21) is a cytokine produced...
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