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Objective
Distinct cognitive subgroups are seen in patients with long duration bipolar I disorder (BDI), possibly reflective of underlying pathophysiological differences. It is unknown whether such cognitive heterogeneity is present at illness onset. We applied latent class analysis (LCA) to cognitive test scores in first episode BDI patients. Exploratory analysis elucidated whether impaired subgroups...
The Homer family of postsynaptic scaffolding proteins plays a crucial role in glutamate-mediated synaptic plasticity, a phenotype associated with Bipolar Disorder (BD). Homer is a target for antidepressants and mood stabilizers. The AA risk genotype of the Homer rs7713917 A>G SNP has been associated with mood disorders and suicide, and in healthy humans with brain function. Despite the evidence...
Brain-imaging studies offer the possibility of advancing our knowledge of the neural correlates of mood regulation, which may ultimately lead to a more biologically meaningful approach to mood disorders. Knowledge of the pathophysiology of mood disorders is increasing steadily and will continue to do so as more sophisticated brain-imaging techniques become available. At present, most studies use magnetic...
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