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HER-2/neu, a protein often giving higher aggressiveness in breast cancers, has been shown that if the gene is expanded for some reason, the Her-2 protein produced by the cells will be over-expressed to enhance the cancer cells reproduced ability, the prognosis will be also relatively less, too. The HER-2 immunohistochemical stained provides a simple and reliable method for pathologist in clinical...
Cell polarity is involved in many biological functions such as development, wound healing and immune responses. In human neutrophils, polarization is characterized by the translocation of distinct sets of signaling molecules to opposite ends of the cell and the rapid rearrangement of cytoskeleton to initiate migration. While many image-based studies have described cellular morphology and the intensity...
This paper proposes a new technique for solving jigsaw puzzles. The novelty of the proposed technique is that it provides an automatic jigsaw puzzle solution without any initial restriction about the shape of pieces, the number of neighbor pieces, etc. The proposed technique uses both curve- and color-matching similarity features. A recurrent procedure is applied, which compares and merges puzzle...
Matching two images with similar contents is one of the most fundamental tasks in image processing. Due to its importance, in recent years, many novel techniques have been proposed with great successes. Toward this effort, in this paper, we propose a radically different idea by bridging two seemingly unrelated fields - Image Processing and Biology - i.e., we propose to use the popular gene sequence...
In this paper, we present a robust methodology for image registration, segmentation, and feature extraction for protein microarrays. Originally designed for application to an Agilent microarray platform, the algorithms used are easily adapted to other platforms. Linear and nonlinear filtering techniques are used to identify protein signals on the array. After signal identification, expression values...
The identification of protein-protein interactions along with their spatial and temporal localization is vital data for assigning functional information to proteins. Historically, these data sets obtained from fluorescence microscopy, have been analyzed manually, a process that is both time consuming and tedious. The development of an automated system that can measure the location dynamics of the...
We investigate automatic classification of protein crystallization imagery, and evaluate the performance of several modern mathematical tools when applied to the problem. For feature extraction, we try a combination of geometric and texture features; for classification algorithms, the support vector machine (SVM) is compared with an automatic decision-tree classifier. Experimental results from 520...
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