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MicroRNAs are one type of noncoding RNA that regulate their target mRNAs before mRNAs are translated into proteins. Although it has been demonstrated that the regulation is through partial binding of the seed region of a miRNA and its targets, the mechanism of this process is not fully discovered. Some biological experiments have shown that even perfect base pairing in the seed region does not always...
In this paper, we exploit the level set methods to extract and analyze the feature of macromolecular field. For the 3D volume data of the field, we propose a novel variational formulation of the geometric active contour, which is composed of an external energy to drive the active contours' motion, and an internal energy which penalizes the level set function adoptively to avoid periodically re-initializing...
The following topics are dealt with: protein-protein interaction; cancer informatics; disease informatics; protein folding; gene networks; biosequence analysis; biochemical modeling; microarray analysis; biological theory; medical informatics; RNA structure; and RNA function
Due to the relatively large gap of knowledge between gene identification and gene function, the ability to construct a computational model describing gene function from sequence information has become an important area of research. In order to understand the biological role of a specific gene, we will require knowledge of the corresponding protein's structure and function. We present a support vector...
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