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The interactions between cardiac metabolism and function at the molecular level are complex, but can be understood in terms of several broad concepts. First, function and metabolism are linked by acute mechanisms involving coupling of ATP demand to ATP synthesis, AMPK activation and various covalent and allosteric modifications of key enzymes, and by transcriptional mechanisms. Second, altered metabolic...
Aims/hypothesis The wingless-type MMTV integration site (WNT) pathway mediates multiple physiological and pathological processes, such as inflammation, angiogenesis and fibrosis. The aim of this study was to investigate whether canonical WNT signalling plays a role in the pathogenesis of diabetic nephropathy. Methods Expression of WNT ligands and frizzled receptors in the canonical WNT pathway in...
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