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Strategies for the efficient synthesis of peptide macrocycles have been a long‐standing goal. In this paper, we demonstrate the use of the peptide ligase termed omniligase‐1 as a versatile and broadly applicable enzymatic tool for peptide cyclization. Several head‐to‐tail (multi)cyclic peptides have been synthesized, including the cyclotide MCoTI‐II. Cyclization and oxidative folding of the cyclotide...
The inside cover picture, provided by Nuijens and co‐workers, illustrates the power and versatility of the peptide ligase omniligase‐1. This ligase provides a promising green and clean alternative to chemical approaches used for peptide cyclization, peptide fragment condensation and protein labelling. The ligations are traceless, proceed with very high catalytic efficiency and result in high product...
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