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The patterns of genetic change, clonal evolution, natural history and latency are very different in the paediatric leukaemias compared with adult epithelial cancers but are similar to those in other childhood cancers of mesenchymal stem cell origin. This distinction has a biological logic in the context of the selective pressures for clonal emergence in different developmental and cellular contexts...
After graduating at University College (BSc) and Middlesex Hospital Medical School (Ph.D), Mel worked at the Karolinska Institute, Stockholm, and the National Institute for Medical Research before joining the Imperial Cancer Research Fund, heading up an immunology laboratory in 1976. In 1984, he was appointed Director of the Leukaemia Research Fund's first specialist centre, at the Institute of Cancer...
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