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Closed-loop systems, where neural signals are used to control electrical stimulation, show promise as powerful experimental platforms and nuanced clinical therapies. To increase the availability, affordability, and usability of these devices, we have created a flexible open source system capable of simultaneous stimulation and recording from multiple electrodes. The system is versatile, functioning...
We report a high-rate, low-power wireless transmission system (named HermesD) to aid the research in neural prosthetics for motor disabilities, by recording and transmitting neural activity from electrode arrays implanted in rhesus monkeys. This system supports the simultaneous transmission of 32 channels of broadband data sampled at 30 kSps, 12 bit/sample, using FSK modulation on a 3.95 GHz carrier,...
Closed-loop neurostimulation has shown great promise as an alternate therapy for over 30% of the epileptic patient population that remain non-responsive to other forms of treatment. We present an event-based seizure detection algorithm that can be implemented in real-time using low power digital CMOS circuits to form an implantable epilepsy prosthesis. Seizures are detected by classifying and marking...
Degenerative chronic spinal cord compression induced cervical myelopathy is a common cause of spinal cord dysfunction. The disease generally leads to impairment of the sensory and motor function of the cord progressively and insidiously. However, the underlying pathophysiology and the precise mechanism of the disease are still uncertain and remain to be investigated. The establishment of an animal...
The aim of this study was to determine the effect of monophasic, biphasic symmetric, and biphasic asymmetric balanced rectangular stimulus waveforms utilized in high-frequency electrical conduction block of nerve fibers. From the animal studies, we found that blocking stimulus with monophasic or biphasic asymmetric waveform at varied blocking current amplitudes showed better blocking effect, which...
Spondyloptosis is a type of severe spinal deformity that develops during childhood and progresses to adulthood. Spondyloptosis causes back pain, limited range of mobility, leg weakness and severe hamstring tightness. Correction of spondyloptosis requires careful preoperative analysis and special surgical techniques to ensure optimal nerve root stretch; both under-stretch and over-stretch pose a danger...
Genetically epileptic EL mice develop the ictogenesis if they receive tossing-up stimulation from 12 weeks old. We investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on the development of ictogenesis in EL mice. Female EL mice have received low (1 Hz)- or high (10 Hz)-frequency rTMS (100% of motor threshold, 300 pulses/day, once a week) from 8 to 19 weeks old. From 12...
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