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Posttranslational processes are essential for generation and dynamics of circadian rhythms in species as diverse as cyanobacteria and human. Historically, circadian rhythm generation at the molecular level was thought to be primarily based on a transcriptional-translational feedback loop, in which negative components inhibit the transcriptional activity of their own activators. Subsequently,...
Smad proteins are key signal transducers for the TGF-β superfamily and are frequently inactivated in human cancers, yet the molecular basis of how their levels and activities are regulated remains unclear. Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-β signaling.
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