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Guanine-rich DNA strands have the potential to activate Cu2+ ions in peroxidase-like reactions based on the coordination of Cu2+ with nucleobases. Comparative studies on the number of guanines elucidate a sequence dependency that contiguous guanines are crucial to intrinsic peroxidase mimicking activities of DNA-Cu(II). The optimal number of repeat units to boost the enzyme-like activity of Cu2+ is...
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