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Due to the heterogeneous nature of schizophrenia, understanding the genetic risk for the disease is a complex task. Gene expression studies have proven to be more reliable than association studies as they are consistently replicated in a tissue specific manner.Using RNA-Seq we analysed gene expression in the frontal cortex of 24 individuals with schizophrenia and 25 unaffected controls.We identified...
Background Advanced paternal age is robustly associated with several human neuropsychiatric disorders, particularly autism. The precise mechanism(s) mediating the paternal age effect are not known, but they are thought to involve the accumulation of de novo (epi)genomic alterations. In this study we investigate differences in the frontal cortex transcriptome in a mouse model...
To explore the difference of gene expression in rat mesenchymal stem cell (MSC) and in the hippocampus of the Alzheimerpsilas disease (AD) model rats on Natural Brain-Kinetine by Gene chips. Methods: Rat MSC is primary cultured according to method-routie. The MSCs have two groups, the control group and treatment group without or with Natural Brain-Kinetine (NBK) respectively. MSCs gene expression...
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