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Aims/Hypothesis. Glucokinase regulatory protein (GKRP) controls the activity of glucokinase in liver but possibly also in some areas of the central nervous system, suggesting that it could play a role in body mass control. Its gene is located in a region (2p2123) linked to serum leptin levels. Our goal was to investigate whether mutations in the GKRP gene were associated with obesity. Methods. Mutations...
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