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Cancer continues to be a major risk to the health and well being among populations around the world. A new method using ion-ionizing radiation with nanosecond pulsed electric fields (nsPEFs) provides a novel means to treat cancer at local sites. NsPEFs promote cell death in several cell types and here we investigated mechanisms for cell death induction. In murine B16f10 melanoma, murine E4 squamous...
The recently proposed exothermic chemical reaction based tumor hyperthermia method presented a new way of realizing truly minimally invasive treatment for tumor. This method utilizes heat generated from the reaction between acid and alkali solutions to allow for tumor ablation. Successful clinical implementation of this method requires a clearer understanding and quantification of the ablation area...
A technique for steering of flexible bevel-tipped needles through tissue, providing proportional control of trajectory curvature by means of duty-cycled rotation or spinning during insertion, has been presented previously, and tested in vitro in gelatin samples. The present paper presents the results of testing under more authentic conditions. Thirty-two needle insertions were performed in cadaver...
Epidermal growth factor receptor (EGFR) is an important cell surface protein that's over-expressed in many human cancer cells. We designed a novel peptide ligand (named D4) based on the crystal structure of EGFR that can bind to a surface pocket on EGFR. D4-PEG-lipid conjugates were made and used to modify liposome surface. Confocal fluorescence microscopy data showed that D4-liposome (D4-RL) bound...
A new platform for oral delivery of paclitaxel (PTX) was developed using a chemical conjugate system between PTX and low molecular weight chitosan (LMWC) having a narrow range of molecular weight (Mw). Three different Mws of chitosan (3k, 6k, and 9k) were used to prepare the conjugates. LMWC-PTX conjugates were synthesized by two step reactions: i) modification of PTX with succinic acid and ii) coupling...
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