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In this article, a new concept of an “endophenotype-associated surrogate endpoint (EASE)” is proposed. To examine effect of a novel therapeutic molecule on a target phenotype of a genotype associated with the molecule, state-dependent aspect of an endophenotype can be used as a surrogate endpoint. Desired characteristics for EASE are (1) a close relationship to the endophenotype associated with therapeutics,...
Affektive Störungen sind Kernsymptome der Schizophrenie. Neuronale Korrelate dieser Veränderungen können mit molekularen, strukturellen und funktionellen Methoden der Bildgebung des Gehirns untersucht werden. In dieser Übersichtsarbeit werden Bildgebungsstudien vorgestellt, mit dem Schwerpunkt auf affektive Symptome und Veränderungen in der emotionalen Verarbeitung bei schizophrenen Patienten. Studien...
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