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Schizophrenia is associated with abnormalities of hippocampal structure and function. Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia. Here we explore GABAergic mechanisms of this hippocampal hyperactivity.The initial evidence for GABAergic abnormalities of the hippocampus in schizophrenia came from post-mortem studies of interneuron number, protein expression,...
For several decades the main focus of neurochemical research in schizophrenia has been on the dopamine hypothesis. Certainly the primary action of antipsychotic drugs is to diminish dopamine D2 receptor-mediated neurotransmission. Although there is little indication of a primary disturbance in dopamine neurotransmission in the disease, recent functional neuroimaging studies have demonstrated an increase...
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