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Imaging evidence indicates that brain alterations are primary to the full-blown onset of schizophrenia and seem to progress across time. The potential effects of antipsychotic medication on brain structure represent a key factor in understanding brain changes in psychosis. We aimed to investigate the effects of low doses of haloperidol, risperidone and olanzapine on cortical thickness.We investigated...
For several decades the main focus of neurochemical research in schizophrenia has been on the dopamine hypothesis. Certainly the primary action of antipsychotic drugs is to diminish dopamine D2 receptor-mediated neurotransmission. Although there is little indication of a primary disturbance in dopamine neurotransmission in the disease, recent functional neuroimaging studies have demonstrated an increase...
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