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Recently titiania nanotubes show their potential in implant application, however their cytocompatibility are still controversial. In previous reports concerning the cytocompatibility of titania nanotube, someone annealed the titania nanotube to transform it from amorphous into anatase type while others didn't. It's believed by some people that the anatase type of titania may benefit osseointegration...
In this work, a thin layer of TiO2 is produced on the NiTi surface using oxygen plasma immersion ion implantation (O-PIII), followed by anodization in electrolytes to induce the formation of a nanotubular layer. Finally, calcium PIII is conducted to fill the TiO2 nanotubes with calcium. Inductively-coupled plasma mass spectrometry (ICPMS) results reveal that nickel leaching can be effectively suppressed...
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