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Histamine is an important biogenic amine, which acts with a group of four G-protein coupled receptors (GPCRs), namely H1 to H4 (H1R – H4R) receptors. The actions of histamine at H4R are related to immunological and inflammatory processes, particularly in pathophysiology of asthma, and H4R ligands having antagonistic properties could be helpful as antiinflammatory agents. In this work, molecular modeling...
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