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Near-infrared spectroscopy (NIRS) is a non-invasive neuroimaging technique that recently has been used to measure changes in cerebral blood oxygenation associated with brain activity. Numbers of research groups have applied general linear model (GLM) based method to analyze the NIRS data. However, classical GLM based method cannot provide on-line analysis. Therefore, its usage is constrained in processing...
Functional near-infrared spectroscopy (fNIRS) was used to study changes in cerebral blood oxygenation during a verbal fluency task. Five right-handed male volunteers matched on demographic variables and verbal fluency performance participated in the study. Images were acquired over 5 minutes at 1.5 T while the subjects performed two tasks. The first involved paced silent generation of words beginning...
Brain's functional response can be studied by observing the spatiotemporal dynamics of functional and structural changes in cerebral vasculature. However, very few studies explore detailed changes at the level of individual microvessels while revealing the simultaneous wide field view of microcirculation responses to functional stimulation. Here we use a high spatiotemporal resolution laser speckle...
Linear array based micro-ultrasound provides 40150um resolution over a significant depth of field at frames rates as high as 1000 fps. Current imaging modalities for investigating in vivo brain function are challenged to provide this combination of imaging parameters. The present experiment was carried out to investigate the potential of micro-ultrasound in neuroimaging of rodents in vivo. Adult male...
Deep tissue multiphoton imaging of mouse brain using 1280-nm excitation is presented. Approximately 1-mm imaging depth is achieved in adult mice in vivo. Blood flow measurements at a depth of 900 mum are performed.
A laser speckle imaging (LSI) technique, with high spatio-temporal resolution, is presented for studying cerebrovascular response to stimulation. LSI is evaluated in a rodent model of cerebrovascular activity, in a model of migraine, by eliciting functional response to brain trigeminal nerve stimulation. The specific haemodynamic response, including deoxy-hemoglobin saturation and blood flow responses...
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