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Endothelial dysfunction is an early indicator of developing atherosclerosis and is a strong predictor of future heart attack and stroke. At present, evaluation of endothelial function (EF) (specifically, EF mediated by nitric oxide, NO) is too technically difficult to form part of a routine clinical examination. Non-invasive methods that measure NO- dependent EF in arteries make use of a 4-5 minute...
Recent work showed that GSNO reductase (GSNOR) mediates the equilibrium of nitric oxide (NO) and the adduct molecules, S-nitrosothiols (SNOs) in lungs of asthmatic mice, and thus, plays a central role in the physiology and patho-physiology in lung diseases. To further understand the role of GSNOR in mediating asthma development, it is essential to examine the possible factors that can activate GSNOR...
Nitric oxide (NO) is a neurotransmitter strikingly different from others. It is able to diffuse isotropically regardless of intervening cellular or membrane structures; and it exhibits a surprisingly diverse range of biochemical activity. NO diffusion and reactions affect the nervous system significantly. At present there is no effective technique for detecting them in vivo in real time, whereas computational...
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