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Blood vessels are constantly exposed to hemodynamic forces in the form of cyclic stretch and shear stress due to the pulsatile nature of blood flow. Endothelial cells (ECs) lining these blood vessels act as a sensing interface to transduce these hemodynamic forces or mechanical stimuli to intracellular signals. EC signaling leads to the production of nitric oxide (NO) that regulates the flow pressure...
Recent work showed that GSNO reductase (GSNOR) mediates the equilibrium of nitric oxide (NO) and the adduct molecules, S-nitrosothiols (SNOs) in lungs of asthmatic mice, and thus, plays a central role in the physiology and patho-physiology in lung diseases. To further understand the role of GSNOR in mediating asthma development, it is essential to examine the possible factors that can activate GSNOR...
Nitric oxide (NO) is a neurotransmitter strikingly different from others. It is able to diffuse isotropically regardless of intervening cellular or membrane structures; and it exhibits a surprisingly diverse range of biochemical activity. NO diffusion and reactions affect the nervous system significantly. At present there is no effective technique for detecting them in vivo in real time, whereas computational...
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