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The effects of repeated administration of Escherichia coli lipopolysaccharide (LPS) on body temperature and hypothalamic prostaglandin E 2 (PGE 2 ) production was examined in male Sprague-Dawley rats to elucidate whether the development of endotoxin tolerance is related to the ability of the hypothalamus to produce PGE 2 . Initial injection of LPS resulted in hyperthermia,...
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