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Cardiovascular implants including bypass grafts, heart valves and stents are prone to calcification, thrombogenicity and structural failure. To overcome these problems we have developed and patented a family of nanocomposite polymers based on polyhedral oligomeric silsesquioxane (POSS) nanoparticles and poly(carbonate urea)urethane (PCU). In addition, we have been working on bonding bioactive molecules...
Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor cells ongoing apoptosis...
Endothelial dysfunction is an early indicator of developing atherosclerosis and is a strong predictor of future heart attack and stroke. At present, evaluation of endothelial function (EF) (specifically, EF mediated by nitric oxide, NO) is too technically difficult to form part of a routine clinical examination. Non-invasive methods that measure NO- dependent EF in arteries make use of a 4-5 minute...
Hydrogel coatings have been widely researched as a nonfouling surface modification of materials for cardiovascular applications. In this study, we examined cell-surface interactions between a poly(acrylamide-copolyethylene glycol/acrylic acid) interpenetrating network (IPN) hydrogel and aortic endothelial cells (ECs). The IPN was covalently attached to polystyrene to form a nanometer scale thick hydrogel,...
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