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The aim of this study was to investigate sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells. Left ventricular endocardial action potentials were simulated using a modified Luo Rudy model. Sex, age and regional differences in currents ICaL, IKr, IKs, and Ito were incorporated into the model by modifying the...
Recent studies demonstrated that the vulnerable window was wider when the premature beat was initiated in the endocardium than in the epicardium. Because acute ischemia causes extensive electrical remodeling to the myocardium, we sought to determine if the same disparity of vulnerability due to the location of premature beat existed in acute ischemia. A numerical model that could reproduce the three...
Objectives. The aim of this work is to provide a quantitative analysis of cardiac repolarization time (RT) markers derived from unipolar electrograms (EGs) and hybrid monophasic action potentials (HMAPs) under normal and ischemic conditions. These markers are compared with the gold standard RT markers based on the transmembrane action potential (TAP). Methods. The analysis is based on large scale...
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