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Today, one of the limitations associated with cartilage grafting is the lack of bonding between the implanted materials and the natural tissue. Helical rosette nanotubes (HRNs) are novel biomimetic self-assembled supramolecular structures whose basic building blocks are DNA base-pairs, which can solidify into a viscous gel at body temperatures in short periods of time. HRNs are similar in size to...
Utilization of enzyme catalysis as a tool to disassemble self-assembled hydrogels to control the release encapsulated drug provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators (LMWGs). Herein, we report a novel approach for controlled delivery of multiple drugs by an enzyme triggered hydrogel degradation mechanism. In this proof-of-concept work, we report...
The integration of cell culture and characterization onto a miniaturized platform promises to benefit many applications such as tissue engineering, drug screening, and those involving small, precious cell populations. This paper presents the controlled on-chip gelation of a thermally-reversible hydrogel. Channel design and flowrate control are crucial in determining hydrogel geometry, while integrated...
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