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The sinoatrial node (cardiac pacemaker) cell spontaneously generates periodic electrical signals (action potentials), and the action potential generation is deeply related to various ion channels in its cell membrane. The abnormalities of ion channels cause serious sinus arrhythmia, and such diseases are usually treated by applying drugs which have effects on ion channels. This paper uses the Zhang...
Abnormalities in cardiac repolarization have been implicated in cardiac arrhythmogenesis caused by disease, mutations and drugs. Of particular concern for regulatory agencies, pharmaceutical industry and society is the fact that certain drugs, in particular those not designed to affect the heart, can exhibit cardio-toxicity (i.e.unwanted side effects), which can put patients at risk of developing...
We used principal component analysis (PCA) of the QRS complex to assess depolarisation heterogeity during ajmaline test in 96 patients with suspected Brugada Syndrome (BS). PCA was performed on 15-lead ECGs (12 leads +V1, V2 and V3 from 3rd intercostal space, V1h to V3h using a) V1, V2 and V3 (QRS-PCAstand), b) V1h, V2h and V3h (QRS-PCAhigh), and c) V1 to V3, V1h to V3h (QRS-PCAtotal). Among patients...
Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed...
In recent years, a revolution has taken place in cardiology to bring forth a new, minimally invasive interventional procedure: microwave transcatheter ablation for cardiac arrhythmias. The development of cardiac ablation using microwave energy was reported in 1987, the same year that the initial clinical use of RF energy for the ablation of cardiac arrhythmias appeared. However, clinical trials of...
Fibrillatory rhythms are poorly characterized by traditional time-domain measures, such as rate. The authors describe two measures not commonly applied in intracardiac signal processing; the median frequency (MF) in the 2 to 9 Hz region of the power spectrum, and the magnitude-squared coherence (MSC) function. These two measures are formally defined. The MF is a robust measure of drug-induced changes...
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