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Diazepam is an active ingredient of the drugs which is used in the treatment of the anxiety, insomnia, alcohol withdrawal, and muscle spasm. It has anxiolytic, sedative, muscle relaxant and memory weakening effects. Diazepam is also administrated before surgical operations that require only local anesthesia, to prevent possible anxiety. In this study, we aimed at assessing differences in anxiety levels...
This study examines the effects of changing oxygen fractional inspiration ratio (FiO2), and nitrous oxide (N2O) for the improvement of cardiovascular control of mean arterial blood pressure (MAP) and heart rate (HR) in C57BL/6 mice under isoflurane anesthesia (1.5%) for up to 90 minutes post-induction. Heart rate variability (HRV) indices are also quantified under these conditions. The results indicate...
Monitored anesthesia care (MAC) is increasingly used to provide patient comfort for diagnostic and minor surgical procedures. The drugs used in this setting can cause profound respiratory depression even in the therapeutic concentration range. Titration to effect suffers from the difficulty to predict adequate analgesia prior to application of a stimulus, making titration to a continuously measurable...
The maintenance of adequate anesthesia is very important for animal studies. This goal could be achieved if the pharmacokinetics of the anesthetic is known and a well-controlled instrument system is used. To this end, a graphic control system is developed to study the effects of sodium pentobarbital on anesthesia. Hemodynamic signals such as mean blood pressure, pulse pressure, heart rate were analyzed...
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