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Carbon nanotubes (CNTs) have been widely investigated as one of the most promising nanomaterials in biomedical applications. Functionalization of CNTs with poly(ethylene glycol) diamine (PEG) is a recognized methodology with good solubility and biocompatibility. In this study, PEG conjugated (PEGylated) multi-walled CNTs (MWCNTs) were prepared and labeled with fluorophore FITC. Using fluorophore-conjugated...
Electroporation is the technique of applying high intensity, short duration pulses for effective drug/gene delivery for cancer therapies when conventional treatments do not work and/or costly with serious side effects and for chemo-resistive patients. Typically micro and millisecond pulses have been used by several researchers. Use of nanosecond pulse is gaining momentum due to its various advantages...
Summary form only given. The success of the extracorporeal shock wave lithotripsy in non-invasive treating patients with stone deceases (mostly kidney stones) stimulated research on applications of focused shock waves in other branches of medicine such as for noninvasive treatment of cancer tissues and a targeted drug delivery. However, there is a fundamental difference in treatment of kidney stones...
To explore the preparation and characters of a novel nanosized magnetic liposome that contained PEI-As2O3/Mn0.5Zn0.5Fe2O4 (PEI- As2O3/MZF) complex. Experimental results suggest that PEI-As2O3/MZF magnetic nanoliposome is a kind of appropriate material which has multiple effects for tumor thermotherapy, gene therapy and chemotherapy.
Liposomes are nanoparticles consisting of phospholipid-bilayer membranes and aqueous compartments. They can effectively incorporate both hydrophobic and hydrophilic molecules, and therefore have been widely applied as a carrier for gene and drug delivery. Moreover, liposomes are considered as a novel vaccine delivery system, which encapsulate both Antigen (Ag) and immunomodulatory agents, facilitating...
Presented in this paper are our investigations on the application of short duration (milli and micro seconds) electrical voltage pulses for the treatment of breast carcinoma cells and also for delivering molecules into adult mesenchymal stem cells. Since current therapies do not work effectively for many patients, there is a need for alternative, affordable, yet effective treatments for various cancers...
Recently, micro- and nano-technologies have enabled rapid progress in biomedical applications. Although in vitro analytical and diagnostic tools have been the focus of such technologies, in vivo therapeutic and sensing applications have received significant attention in the past few years. Novel implantable drug delivery devices, which can precisely control key therapy parameters, have the potential...
The next generation of implantable biomedical devices based on micro- and nano-electro-mechanical systems (MEMS and NEMS) technology is presented for diagnostics and treatment of chronic and non-chronic illnesses. These passive and active implantable devices allow for early diagnostics as well as timely and precisely controlled therapeutic drug delivery. The implantable devices are also applicable...
Studies of the biological relevance of nanocarbon materials have attracted much attention. While the scientific community has primarily focused on the potential biological applications of fullerenes and carbon nanotubes, another important form of nanocarbon materials, nanodiamonds (NDs), are beginning to emerge as alternative candidates for similar and other applications due to their high biocompatibility,...
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