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Neurodegenerative diseases (NDs), including the most prevalent Alzheimer’s disease and Parkinson disease, share common pathological features. Despite decades of gene‐centric approaches, the molecular mechanisms underlying these diseases remain widely elusive. In recent years, transposable elements (TEs), long considered ‘junk’ DNA, have gained growing interest as pathogenic players in NDs. Age is...
In recent years there has been a wide interest toward zinc metalloproteases involved in neurodegenerative diseases. Enzymes such as matrix metalloproteases, neprilysin, insulin degrading enzyme, etc. play a pivotal role in the homeostasis of peptides and proteins whose accumulation and fibrillation seem to be the major cause for the development of such diseases. It is also well known that chemical...
Oxidative stress has contributed a lot towards neurodegenerative diseases such as the Alzheimer's and Parkinson's diseases. One of the main factors of oxidative stress is reactive oxygen species (ROS). This research aimed to determine both the possible neurotoxic and neuroprotective effects of herbal extracts (designated as NHA56). This tablet-form medicine was claimed to be effective against muscle...
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