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This study demonstrates that adult neural stem cells (NSC) exhibit a differential response to endothelial cell (EC) derived extracellular matrix (ECM) produced under hemodynamic flow compared to statically produced ECM. In vivo, NSC reside in close proximity to blood vessels, suggesting that EC-produced factors may influence NSC fate. In vitro, it has been demonstrated that soluble factors released...
Intracranial aneurysms are pathological dilatations of the arterial wall. Hemodynamic factors like the wall shear stress play an important role in the formation, growth and rupture of intracranial aneurysms; however, their natural growing history is not well understood. In this paper, we created 3-D models of intracranial aneurysms based on patient-specific 3DRA images and performed hemodynamic numerical...
Long term monotonous driving has been often found to decrease the driver's arousal level and effect his/hers property of perception, cognition and judgment. It is preferable to apply arousal assist for the driver instead of huge stimulus such as warning sound and vibration to the driver while driving. On the other hand, the effect of the scent is also reported as an environmental stimulus for driver...
The effect of intracerebroventricular infusions of C-type natriuretic peptide (CNP-22, 5 μg/h for 3 h) or vehicle on the neurohumoral response of conscious sheep (n = 7) to acute moderate hemorrhage (15 ml/kg in 15 min performed 1 h after start of CNP) was studied. CNP alone (prehemorrhage) induced a transient rise (after 30 min) in heart rate (p = 0.0005), plasma aldosterone (p = 0.007), ACTH (p...
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