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The adult renal tumors are represented for about 90% by renal cell carcinoma (RCC). These epithelial malignant neoplasms are subclassified in five main types: conventional or common RCC, including clear and eosinophilic cell carcinoma, chromophobe RCC, papillary (or chromophilic) RCC, collecting duct carcinoma and RCC unclassified. This classification, proposed and accepted in the Heidelberg Workshop...
We characterize the genetic abnormalities associated with pathological subtypes of renal tumors, which may help diagnosis or prognostication. A comprehensive literature review of genetic abnormalities associated with different renal tumor subtypes was performed. Studies of sporadic and hereditary forms suggest that abnormalities in the von Hippel-Lindau and met genes are the earliest changes...
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