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Using microdialysis in the prefrontal cortex, this study investigated first the effects of the ionotropic glutamatergic agonists NMDA and AMPA on extracellular concentrations of GABA, and second, the modulation of these effects by increasing endogenous dopamine. NMDA (20, 100, and 500 μM) and AMPA (1, 20, and 100 μM), perfused through the microdialysis probe for 60 min, produced a dose-related increase...
Using microdialysis, the effects of endogenous dopamine on basal extracellular concentrations of γ-aminobutyric acid (GABA) and on the increases of GABA produced by glutamate were investigated in the medial prefrontal cortex of the awake rat. The dopamine uptake inhibitor nomifensine (1, 100 and 1000 μM), used to increase extracellular dopamine, produced a dose-related increase of dialysate dopamine...
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