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Transgenic approaches have been applied to generate transgenic rats that express exogenous genes in arginine vasopressin (AVP)‐ and oxytocin (OXT)‐producing magnocellular neurosecretory cells (MNCs) of the hypothalamic‐neurohypophyseal system (HNS). First, the fusion gene that expresses AVP‐enhanced green fluorescent protein (eGFP) and OXT‐monomeric red fluorescent protein 1 (mRFP1) was used to visualize...
Background
Hypothalamic corticotropin‐releasing factor (CRF) receptor 1 (CRF1) plays a role in acute stress‐related stimulation of colonic motor function. Less is known on CRF1 signaling in the brainstem.
Methods
We investigate CRF1 expression in the brainstem and the colonic response to 4th ventricle (4V) injection of CRF and urocortin (Ucn) 2 (3 µg/rat) in chronically cannulated male rats.
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