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Studienziel. Untersuchung der Expression der Proteintyrosinkinasen Focal Adhesion Kinase (FAK) und Proline Rich Tyrosine Kinase2 (Pyk2) in hochmalignen Osteosarkomen. Material und Methode. Die Expression der Kinasen wurde qualitativ ber immunhistochemische Frbung und quantitativ ber Real-Time-PCR untersucht. Ergebnisse. Osteoblastische Zellen in hochmalignen Osteosarkomen zeigen eine deutliche FAK-Expression,...
Overexpression and amplification of several genes (MDM2, CDK4 and SAS) located on chromosome 12q13-15 have been noted to occur in various human sarcomas. As a result, two major growth regulation pathways may be inhibited. MDM2 may down regulate the p53-mediated growth control and CDK4 may affect pRB-mediated events. To determine the frequency of alterations in these genes and their correlation with...
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