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Optimal image quality in small animal positron emission tomography (PET) is critical to ensure accuracy and reliability of results obtained in biological studies. Indeed, unstable image quality over time can jeopardize longitudinal studies. This is why quality control (QC) procedures are of the utmost importance in order to keep PET scanners at an optimal performance level. Unfortunately, as the scanner...
Stticon Photomultiplier (SiPM) is a promising sensor for PET with a number of advantages. A traditional design for PET detector module is using a pixelated scintillator array coupled to a SiPM array, and it is critical to design reflectors between crystals to decode photon event location. Unlike PMT based detectors, the pixelated scintillator array may not necessarily require complex reflector schemes...
We are developing an imaging system that enables the brain of a freely moving animal to be imaged with microPET while simultaneously observing its behaviour. Towards this end, we investigated the feasibility of reconstructing a motion-tracked volume of interest (VOI) in the presence of an extraneous activity compartment with unknown motion. A dual phantom study was performed to simulate movements...
A full ring small animal PET camera (MiniPET-II) has been built in our institute as part of an R+D project. In this work we determined the performance parameters of the MiniPET-II scanner. The measurements and data evaluation for this purpose were based on the National Electrical Manufacturers Association (NEMA) NU-4 standards. The spatial resolution varies between 1.4 to 2.1 mm from central to 25...
Volume-of-interest (VOI) segmentation is an important prerequisite for quantitative analysis of structure and function in multimodal tomographic images (e.g., MRI, CT, PET, SPECT images) of humans and small animals. A suitable VOI segmentation method should allow user interaction to position the VOI where desired and be automated to support the user as much as possible. Thus, semiautomatic methods...
The goal of this work was to improve the image quality of small animal PET images by introducing in the reconstruction process the true system point spread function (PSF) and an anatomical image prior. Simulations were performed using a mouse heart phantom (myocardium and ventricles) and a comparison between standard EM reconstruction and EM with PSF modelling and anatomical prior was performed. The...
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